The challenge for Athletic Bilbao, as usual, will stop Cristiano Ronaldo.
Just days after reaching the final of the Copa del Rey, Athletic will host Real Madrid and winger in the League Saturday, Spain.
Ronaldo has 39 goals in 36 matches this season, including a single goal the team drew 1-1 against Villarreal last weekend.
Madrid's coach Carlo Ancelotti said that, barring unforeseen injuries, Ronaldo will be accompanied home by Gareth Bale and Karim Benzema, the Madrid attacks makes the most powerful.
Barcelona, which also reached the Copa del Rey final, hosts Rayo Vallecano on Sunday, while Atletico Madrid host Valencia.
Here are some things to know about this weekend's matches:
Without Griezmann: Atletico Madrid Coach Diego Simeone rely heavily on France striker Antoine Griezmann, after playing him in 38 of the team's 40 games.
But Griezmann, was suspended for the match against Valencia at the Vicente Calderon Stadium because of an accumulation of yellow cards.
Atletico have failed to win one game that doesn't play on. Griezmann
It is third in the standings, winning fourth place one point from Valencia.
BALE'S DROUGHT: Bale arrived at Real Madrid for a world record fee of $ 132.000.000, but the Welsh midfielder had not found the back of the net in five games. The former Tottenham player has 14 goals in 35 games this season.
Barcelona Midfielder Busquets OUT: Sergio Busquets was taken from the field by stretcher on Wednesday during a 3-1 win over Villarreal, which ruled him out of Sunday's match.
Tomas rolled ankles Pina Busquets ' bad when he accidentally landed on it while making a pass.
On Thursday, the team said medical tests confirmed that the Spain midfielder suffered a high ankle sprain and will miss the game against Rayo.
Barcelona have a busy month ahead where Busquets will be a key player, with La Liga match against Eibar, and Rayo then host Manchester City in the UEFA Champions League second leg of 16, and last season the Clásico in Madrid on 22 March.
MADRID emptied the room sick on the ship: once-bustling hospital room in Madrid's ship will soon be empty.
Germany midfielder Sami Khedira, whose left leg muscle injury during the 4-0 loss to Atletico, fully fit and training.
Other players who joined him on the Court at Madrid's Valdebebas training field is Defender Sergio Ramos, striker Karim Benzema and midfielder James